Nearest gene: F11
Most severe consequence: non coding transcript exon variant
AF 4.2e-1(ranges from 4.2e-1 to 4.3e-1 across all phenotypes)
AF in gnomAD genomes 2.1: FIN 4.1e-1, POPMAX 4.0e-1, FIN enrichment vs. NFEE: 1.016
INFO 1.000 (ranges in genotyping batches from 0.955 to 1.000 )
Number of alt homozygotes: 57827
View in Open Targets , gnomAD , UCSC , GWAS Catalog , dbSNP
category | phenotype | beta (se) | p-value | -log10(p) | af cases | af controls | number of samples | UKBB | UKBB N samples |
---|---|---|---|---|---|---|---|---|---|
IX Diseases of the circulatory system (I9_) | Venous thromboembolism | 0.20 | 6.5e-59 | 58.2 | 4.7e-1 | 4.2e-1 | 14454 / 294700 | NA | NA |
IX Diseases of the circulatory system (I9_) | DVT of lower extremities and pulmonary embolism | 0.21 | 4.8e-58 | 57.3 | 4.8e-1 | 4.2e-1 | 12559 / 296595 | NA | NA |
IX Diseases of the circulatory system (I9_) | Pulmonary embolism | 0.23 | 2.1e-41 | 40.7 | 4.8e-1 | 4.2e-1 | 6753 / 301704 | NA | NA |
Cardiometabolic endpoints | Pulmonary heart disease | 0.23 | 2.2e-41 | 40.6 | 4.8e-1 | 4.2e-1 | 6753 / 302401 | NA | NA |
IX Diseases of the circulatory system (I9_) | Pulmonary heart disease, diseases of pulmonary circulation | 0.22 | 4.8e-39 | 38.3 | 4.8e-1 | 4.2e-1 | 7450 / 301704 | NA | NA |
IX Diseases of the circulatory system (I9_) | DVT of lower extremities | 0.20 | 2.0e-32 | 31.7 | 4.7e-1 | 4.2e-1 | 7008 / 267090 | NA | NA |
IX Diseases of the circulatory system (I9_) | Phlebitis and thrombophlebitis (not including DVT) | 0.17 | 1.6e-17 | 16.8 | 4.7e-1 | 4.2e-1 | 5135 / 267090 | NA | NA |
IX Diseases of the circulatory system (I9_) | Other embolism and thrombosis | 0.22 | 5.4e-17 | 16.3 | 4.8e-1 | 4.2e-1 | 2958 / 267090 | NA | NA |
Cardiometabolic endpoints | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (FINNGEN) | 0.074 | 4.8e-15 | 14.3 | 4.4e-1 | 4.2e-1 | 36246 / 156457 | NA | NA |
IX Diseases of the circulatory system (I9_) | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | 0.058 | 1.3e-13 | 12.9 | 4.4e-1 | 4.2e-1 | 42064 / 267090 | NA | NA |