10:121581150:G:A (rs11599804)

Nearest gene: FGFR2

Most severe consequence: intron variant

AF 3.9e-1(ranges from 3.8e-1 to 3.9e-1 across all phenotypes)

AF in gnomAD genomes 2.1: FIN 3.9e-1, POPMAX 3.9e-1, FIN enrichment vs. NFEE: 0.960

INFO 0.997 (ranges in genotyping batches from 0.994 to 0.999 )

Number of alt homozygotes: 49271

View in Open Targets , gnomAD , UCSC , GWAS Catalog , dbSNP

p-values smaller than 1e-10 are shown on a log-log scale
I Certain infectious and parasitic diseases (AB1_)II Neoplasms from hospital discharges (CD2_)II Neoplasms, from cancer register (ICD-O-3)III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D3_)IV Endocrine, nutritional and metabolic diseases (E4_)Diabetes endpointsV Mental and behavioural disorders (F5_)Alcohol related diseasesPsychiatric endpoints from Katri RäikkönenNeurological endpointsVI Diseases of the nervous system (G6_)VII Diseases of the eye and adnexa (H7_)VIII Diseases of the ear and mastoid process (H8_)Cardiometabolic endpointsIX Diseases of the circulatory system (I9_)X Diseases of the respiratory system (J10_)Asthma and related endpointsInterstitial lung disease endpointsCOPD and related endpointsXI Diseases of the digestive system (K11_)Dental endpointsGastrointestinal endpointsXII Diseases of the skin and subcutaneous tissue (L12_)Rheuma endpointsXIII Diseases of the musculoskeletal system and connective tissue (M13_)XIV Diseases of the genitourinary system (N14_)XV Pregnancy, childbirth and the puerperium (O15_)XVI Certain conditions originating in the perinatal period (P16_)XVII Congenital malformations, deformations and chromosomal abnormalities (Q17)XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R18_)XIX Injury, poisoning and certain other consequences of external causes (ST19_)XX External causes of morbidity and mortality (VWXY20_)XXI Factors influencing health status and contact with health services (Z21_)Drug purchase endpointsOperation endpointsDiseases marked as autimmune originDemonstration endpointsMiscellaneous, not yet classified endpointsOther, not yet classified endpoints (same as #MISC)Comorbidities of AsthmaComorbidities of Neurological endpointsComorbidities of COPDComorbidities of DiabetesComorbidities of Gastrointestinal endpointsComorbidities of Interstitial lung disease endpoints-log₁₀p-value024681016254063

3095 total codes
category phenotype beta (se) p-value -log10(p) af cases af controls number of samples UKBB UKBB N samples
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast 0.20 3.6e-49 48.4 4.3e-1 3.9e-1 13178 / 160568 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast (controls excluding all cancers) 0.19 7.1e-47 46.1 4.3e-1 3.9e-1 13178 / 137507 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER2-negative 0.20 1.8e-46 45.7 4.3e-1 3.9e-1 11997 / 161747 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER2-negative (controls excluding all cancers) 0.20 4.9e-45 44.3 4.3e-1 3.9e-1 11997 / 137507 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER-positive (controls excluding all cancers) 0.23 3.8e-39 38.4 4.4e-1 3.9e-1 7222 / 137407 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER-positive 0.22 1.5e-37 36.8 4.4e-1 3.9e-1 7222 / 166115 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER-negative 0.15 7.1e-12 11.2 4.2e-1 3.9e-1 4777 / 161338 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm of breast, HER-negative (controls excluding all cancers) 0.15 1.1e-11 10.9 4.2e-1 3.9e-1 4777 / 137407 NA NA
II Neoplasms, from cancer register (ICD-O-3) Malignant neoplasm 0.044 3.2e-10 9.50 4.0e-1 3.9e-1 60459 / 248695 NA NA
II Neoplasms from hospital discharges (CD2_) Carcinoma in situ of breast (controls excluding all cancers) 0.13 1.8e-4 3.75 4.2e-1 3.9e-1 1873 / 141335 NA NA
Download table data as TSV