9:121786464:T:A (rs186830920)

Nearest gene: DAB2IP

Most severe consequence: downstream gene variant

AF 1.3e-2(ranges from 1.3e-2 to 1.4e-2 across all phenotypes)

AF in gnomAD genomes 2.1: FIN 1.4e-2, POPMAX 5.8e-4, FIN enrichment vs. NFEE: No NFEE in gnomAD

INFO 0.964 (ranges in genotyping batches from 0.813 to 0.984 )

Number of alt homozygotes: 61

View in Open Targets , gnomAD , UCSC , GWAS Catalog , dbSNP

p-values smaller than 1e-10 are shown on a log-log scale
I Certain infectious and parasitic diseases (AB1_)II Neoplasms from hospital discharges (CD2_)II Neoplasms, from cancer register (ICD-O-3)III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D3_)IV Endocrine, nutritional and metabolic diseases (E4_)Diabetes endpointsV Mental and behavioural disorders (F5_)Alcohol related diseasesPsychiatric endpoints from Katri RäikkönenNeurological endpointsVI Diseases of the nervous system (G6_)VII Diseases of the eye and adnexa (H7_)VIII Diseases of the ear and mastoid process (H8_)Cardiometabolic endpointsIX Diseases of the circulatory system (I9_)X Diseases of the respiratory system (J10_)Asthma and related endpointsInterstitial lung disease endpointsCOPD and related endpointsXI Diseases of the digestive system (K11_)Dental endpointsGastrointestinal endpointsXII Diseases of the skin and subcutaneous tissue (L12_)Rheuma endpointsXIII Diseases of the musculoskeletal system and connective tissue (M13_)XIV Diseases of the genitourinary system (N14_)XV Pregnancy, childbirth and the puerperium (O15_)XVI Certain conditions originating in the perinatal period (P16_)XVII Congenital malformations, deformations and chromosomal abnormalities (Q17)XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R18_)XIX Injury, poisoning and certain other consequences of external causes (ST19_)XX External causes of morbidity and mortality (VWXY20_)XXI Factors influencing health status and contact with health services (Z21_)Drug purchase endpointsOperation endpointsDiseases marked as autimmune originDemonstration endpointsMiscellaneous, not yet classified endpointsOther, not yet classified endpoints (same as #MISC)Comorbidities of AsthmaComorbidities of Neurological endpointsComorbidities of COPDComorbidities of DiabetesComorbidities of Gastrointestinal endpointsComorbidities of Interstitial lung disease endpoints-log₁₀p-value0246810162540

3095 total codes
category phenotype beta (se) p-value -log10(p) af cases af controls number of samples UKBB UKBB N samples
IV Endocrine, nutritional and metabolic diseases (E4_) Amyloidosis, other/unspecified 2.1 2.9e-39 38.5 1.2e-1 1.3e-2 299 / 269572 NA NA
IV Endocrine, nutritional and metabolic diseases (E4_) Amyloidosis 2.0 2.2e-36 35.7 9.9e-2 1.3e-2 367 / 269572 NA NA
VII Diseases of the eye and adnexa (H7_) Hereditary corneal dystrophies 1.0 2.3e-7 6.64 3.3e-2 1.3e-2 532 / 294514 NA NA
VII Diseases of the eye and adnexa (H7_) Other disorders of cornea 0.45 4.3e-4 3.36 2.0e-2 1.3e-2 1853 / 294514 NA NA
XIV Diseases of the genitourinary system (N14_) Oligomenorrhoea -0.90 1.6e-3 2.81 5.1e-3 1.3e-2 833 / 94394 NA NA
XXI Factors influencing health status and contact with health services (Z21_) Other problems related to primary support group, including family circumstances 0.33 1.8e-3 2.73 1.8e-2 1.3e-2 2920 / 301545 NA NA
XIII Diseases of the musculoskeletal system and connective tissue (M13_) Achilles tendinitis -0.43 3.3e-3 2.48 8.6e-3 1.3e-2 2415 / 227388 NA NA
VII Diseases of the eye and adnexa (H7_) Lagophthalmos 0.86 4.2e-3 2.38 3.1e-2 1.3e-2 224 / 285029 NA NA
VII Diseases of the eye and adnexa (H7_) Keratitis 0.18 4.6e-3 2.34 1.6e-2 1.3e-2 8645 / 294514 NA NA
IV Endocrine, nutritional and metabolic diseases (E4_) Autoimmune thyroiditis -1.4 4.7e-3 2.33 2.0e-3 1.3e-2 366 / 263704 NA NA
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