Nearest gene: FGFR2
Most severe consequence: intron variant
AF 3.9e-1(ranges from 3.8e-1 to 3.9e-1 across all phenotypes)
AF in gnomAD genomes 2.1: FIN 3.9e-1, POPMAX 3.9e-1, FIN enrichment vs. NFEE: 0.960
INFO 0.997 (ranges in genotyping batches from 0.994 to 0.999 )
Number of alt homozygotes: 49271
View in Open Targets , gnomAD , UCSC , GWAS Catalog , dbSNP
category | phenotype | beta (se) | p-value | -log10(p) | af cases | af controls | number of samples | UKBB | UKBB N samples |
---|---|---|---|---|---|---|---|---|---|
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast | 0.20 | 3.6e-49 | 48.4 | 4.3e-1 | 3.9e-1 | 13178 / 160568 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast (controls excluding all cancers) | 0.19 | 7.1e-47 | 46.1 | 4.3e-1 | 3.9e-1 | 13178 / 137507 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER2-negative | 0.20 | 1.8e-46 | 45.7 | 4.3e-1 | 3.9e-1 | 11997 / 161747 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER2-negative (controls excluding all cancers) | 0.20 | 4.9e-45 | 44.3 | 4.3e-1 | 3.9e-1 | 11997 / 137507 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER-positive (controls excluding all cancers) | 0.23 | 3.8e-39 | 38.4 | 4.4e-1 | 3.9e-1 | 7222 / 137407 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER-positive | 0.22 | 1.5e-37 | 36.8 | 4.4e-1 | 3.9e-1 | 7222 / 166115 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER-negative | 0.15 | 7.1e-12 | 11.2 | 4.2e-1 | 3.9e-1 | 4777 / 161338 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm of breast, HER-negative (controls excluding all cancers) | 0.15 | 1.1e-11 | 10.9 | 4.2e-1 | 3.9e-1 | 4777 / 137407 | NA | NA |
II Neoplasms, from cancer register (ICD-O-3) | Malignant neoplasm | 0.044 | 3.2e-10 | 9.50 | 4.0e-1 | 3.9e-1 | 60459 / 248695 | NA | NA |
II Neoplasms from hospital discharges (CD2_) | Carcinoma in situ of breast (controls excluding all cancers) | 0.13 | 1.8e-4 | 3.75 | 4.2e-1 | 3.9e-1 | 1873 / 141335 | NA | NA |