Nearest gene: FGG
Most severe consequence: downstream gene variant
AF 3.0e-1(ranges from 3.0e-1 to 3.0e-1 across all phenotypes)
AF in gnomAD genomes 2.1: FIN 3.1e-1, POPMAX 4.4e-1, FIN enrichment vs. NFEE: 1.282
INFO 1.000 (ranges in genotyping batches from 0.933 to 1.000 )
Number of alt homozygotes: 29415
View in Open Targets , gnomAD , UCSC , GWAS Catalog , dbSNP
| category | phenotype | beta (se) | p-value | -log10(p) | af cases | af controls | number of samples | UKBB | UKBB N samples |
|---|---|---|---|---|---|---|---|---|---|
| IX Diseases of the circulatory system (I9_) | Venous thromboembolism | 0.20 | 1.3e-51 | 50.9 | 3.4e-1 | 3.0e-1 | 14454 / 294700 | NA | NA |
| IX Diseases of the circulatory system (I9_) | DVT of lower extremities and pulmonary embolism | 0.20 | 1.3e-48 | 47.9 | 3.4e-1 | 3.0e-1 | 12559 / 296595 | NA | NA |
| Cardiometabolic endpoints | Pulmonary heart disease | 0.25 | 9.4e-44 | 43.0 | 3.6e-1 | 3.0e-1 | 6753 / 302401 | NA | NA |
| IX Diseases of the circulatory system (I9_) | Pulmonary embolism | 0.25 | 1.4e-43 | 42.9 | 3.6e-1 | 3.0e-1 | 6753 / 301704 | NA | NA |
| IX Diseases of the circulatory system (I9_) | Pulmonary heart disease, diseases of pulmonary circulation | 0.22 | 2.6e-36 | 35.6 | 3.5e-1 | 3.0e-1 | 7450 / 301704 | NA | NA |
| IX Diseases of the circulatory system (I9_) | DVT of lower extremities | 0.19 | 1.6e-24 | 23.8 | 3.4e-1 | 3.0e-1 | 7008 / 267090 | NA | NA |
| IX Diseases of the circulatory system (I9_) | Phlebitis and thrombophlebitis (not including DVT) | 0.20 | 4.1e-21 | 20.4 | 3.4e-1 | 3.0e-1 | 5135 / 267090 | NA | NA |
| IX Diseases of the circulatory system (I9_) | Other embolism and thrombosis | 0.24 | 2.8e-18 | 17.6 | 3.5e-1 | 3.0e-1 | 2958 / 267090 | NA | NA |
| Cardiometabolic endpoints | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified (FINNGEN) | 0.076 | 7.6e-14 | 13.1 | 3.1e-1 | 3.0e-1 | 36246 / 156457 | NA | NA |
| IX Diseases of the circulatory system (I9_) | Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified | 0.052 | 4.1e-10 | 9.38 | 3.1e-1 | 3.0e-1 | 42064 / 267090 | NA | NA |